PREPARATIONS:
Axid Oral Solution: 15mg/ml. It is formulated as a clear, yellow, oral
solution with a bubble gum flavor.
Capsules: 150mg, 300mg
Tablet: 75mg
THINGS TO BE AWARE OF:
- Nizatidine is a histamine H2 antagonist. It works by reducing acid
in the stomach by blocking one of the chemicals (histamine) that
stimulates the production of stomach acid.
- Nizatadine is very weight sensitive and should be adjusted regularly
with weight gain.
- Do not take an hour either side of antacids i.e. Mylanta/Maalox as
it will decrease its effectiveness.
- It is best to space this med an hour either side of a PPI i.e.
prevacid or prilosec, as it may interfere with absorption but also be
too hard on a child’s stomach all that once.
- May be taken with or without food, though most prefer to administer
it 30mins before feeding.
STORAGE:
Store nizatidine at room temperature away from
moisture, heat, and light.
PEDIATRIC DOSING:
The unlabeled dosing for children under 12 years is 10mg/kg/day
divided.
Please see you doctor for dosing advice.
OTHER USES:
Treatment of erosive esophagitis, duodenal ulcers and
gastric ulcers. Also maintenance of healing of
duodenal and gastric ulcers.
DRUG INTERACTIONS:
If nizatidine is taken with certain other drugs, the effects of either
could be increased, decreased, or altered. It is especially important to
check with your doctor before combining nizatidine with aspirin,
especially in high doses.
Anticoagulants (e.g., warfarin), beta-blockers (e.g., propranolol),
bupivacaine, ethanol, hydantoins (e.g., phenytoin), nifedipine,
procainamide, sulfonylureas (e.g., glipizide), theophylline, or triazolam
because the actions and side effects of these medicines may be increased
Sucralfate, (carafete) Nondepolarizing muscle relaxants (e.g., vecuronium)
because the effectiveness of nizatidine may be decreased
SIDE EFFECTS:
Abdominal pain, diarrhea, constipation, dizziness, drowsiness, gas, headache, indigestion, nausea, pain, sore throat, vomiting, weakness, coughing and sweating. It is noted that side effects are more common in nizatidine than other H2 antagonists.
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