PREPARATIONS: Tablets: 40 mg. An intravenous form of pantoprazole
is expected soon.STORAGE
Store at room temperature, 15-30°C (59-86°F). Keep away from moisture.
OTHER USES
Although pantoprazole is approved for the treatment of gastro
esophageal reflux disease (GERD), like other proton pump inhibitors it
also is used for treating ulcers of the stomach and duodenum, and the
Zollinger-Ellison Syndrome.
PEDIATRIC DOSING
Currently not FDA approved in the treatment of children and infants.
For GERD the recommended dose for adults is 40 mg daily for 4-8 weeks.
It generally is recommended that tablets be taken approximately 30
minutes prior to meals for maximal effectiveness. Tablets should be
swallowed whole and should not be crushed, split or chewed.
DRUG INTERACTIONS
The absorption of certain drugs may be affected by stomach acidity. It
has been found that PPI’s reduce stomach acid also reduce the absorption
and concentration in blood of ketoconazole (Nizoral) so it has a reduced
effectiveness and increase the absorption. It has also been found to and
concentration in blood of digoxin (Lanoxin) hence an increased toxicity.
SIDE EFFECTS
Pantoprazole like other PPI’s is well-tolerated. The most common side
effects are diarrhea, nausea, vomiting, constipation, rash and headaches.
Dizziness, nervousness, abnormal heartbeat, muscle pain, weakness, leg
cramps and water retention rarely occur. |
